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World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Map Ave Pf 89.5: Guidelines for the Evaluation of Plasmodium Falctpariiof Asexual Blood-Stage Vaccines in Populations Exposed to Natural Infection

By World Health Organization

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Book Id: WPLBN0000210074
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Reproduction Date: 2005
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Title: World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Map Ave Pf 89.5: Guidelines for the Evaluation of Plasmodium Falctpariiof Asexual Blood-Stage Vaccines in Populations Exposed to Natural Infection  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Map Ave Pf 89.5. Retrieved from http://www.worldjournal.org/


Description
Medical Reference Publication

Excerpt
INTRODUCTION Rr-ent. dcvolopments i n immunology and s o l e c u l a r biology i n d i c a t e t h a t viiccirlrs ngainst malaria a r e on the horizon. There a r e t h r e e main aliproaches to malarin vnccine development, hssed on d i f f e r e n t s t a g e s i n the l i f e cycle of o~rlr liresont docu~ner~lc,o nsiders the evalunlion of P. f a l c i ~ a r u m i>sc?xuoi 1:)loori-sl:nge vaccines i r r populations exposed tn n a t u r a l challenge

Table of Contents
CONTENTS INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A. GENERAL BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . 3 1. Development of Plasmodium falcf,narurn asexual blood-stage vaccines . . . . . . . . . . . . . . . . . . . . . . 3 2. The possihle parasitological and clinical consequences o f immunization with P. falcivarum asexual blood-stage vaccines , . 3 3. Asexual blood-stage vaccines and malaria control . . . 5 L. Factors likely ro affect the outcome of z. fnlcinarum asexual blood-stage vaccine trials . . . . . . . . . . . 6 R. FIELD TRIALS IN MALARIA-ENDEMIC COUNTRIES . . . . . . . . . . . . . 8 1. Objectives . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. Information required from early clinical trials (PhaseIandPhaseII) . . . . . . . . . . . . . . . . . . . . . 9 3. Criteria for the selection of areas/populations forfieldtrials . . . . . . . . . . . . . . . . . . . 10 L Background information required to design a trial . . . 21 5. Trialdesign . . . . . . . . . . . . . . . . . . . 13 6. Implementation . . . . . . . . . . . . . . . . . . . . . 17 7. Ethical considerations . . . . . . . . . . . . . 20 C. SELECTED REFERENCES . . . . . . . . . . . . . . . . . . . . . . . 21 ANNEX 1 - METHODS OF MEASUREMENT . . . . . . . . . . . . . . . 26 ANNEX I1 - CANDIDATE ANTIGENS FOR INCLUSION IN VACCINES . . . . . . . . . 30 ANNEX I11 - RESEARCH TOPTCS RELEVANT TO VACCINE TRIALS . . . . . . . . . 33

 
 


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